Protein Modification Reagents
Medchemexpress LLC Endo-BCN-PEG2-alcohol | 1807501-85-4 | 98.0% | C17H27NO5 | 10MG
endo-BCN-PEG2-alcohol is a PEG-based linker that combines a strained bicyclo[6.1.0]non-4-yne (BCN) reactive group with a terminal hydroxyl. It is intended for use in copper-free click chemistry, bioconjugation, and linker assembly in PROTAC synthesis.
- Contains BCN strained alkyne for copper-free click reactions.
- Terminal alcohol enables further functionalization.
- PEG2 spacer increases hydrophilicity and reduces steric hindrance.
- Suitable for PROTAC linker assembly and bioconjugation applications.
- Comes with analytical documentation and storage recommendations.
Medchemexpress LLC Nh2-peg4-dota | 2090232-34-9 | 97.0% | 622.71 | C26H50N6O11 | 25mg
NH2-PEG4-DOTA is a bifunctional DOTA-type metal chelator NH2-PEG4-DOTA can be conjugated with Dextran for quantitative analysis in the presence of a highly luminescent complex NH2-PEG4-DOTA can also bind to radionuclides to prepare radionuclide drug conjugates (RDCs) RDCs have the ability to specifically target biomolecules and can be used in medical imaging or therapy
Medchemexpress LLC t-Boc-N-amido-PEG5-Tos | 1404111-69-8 | MFCD34596623 | 96.0% | 491.60 | C22H37NO9S | 250 MG
t-Boc-N-amido-PEG5-Tos is a Boc-protected PEG5 linker bearing a tosyl leaving group. The hydrophilic PEG spacer improves solubility of conjugates, the tosyl enables efficient nucleophilic substitution, and the Boc group can be removed under mild acidic conditions to expose a primary amine. The reagent is intended for synthetic chemistry and bioconjugation applications.
- Hydrophilic PEG5 spacer improves aqueous solubility.
- Tosyl leaving group facilitates nucleophilic substitution.
- Boc-protected amine allows orthogonal deprotection strategies.
- Suitable for linker construction, bioconjugation, and PROTAC synthesis.
- Available in small research quantities for laboratory use.
Medchemexpress LLC Puromycin-bis(PEG2-amide)-Biotin | 2379889-82-2 | 98.8% | 1046.20 | 5 MG
Puromycin-bis(PEG2-amide)-Biotin is a binding molecule that targets ribosome-RNA complexes within single cells. It is specifically designed for use in single-cell translatome sequencing applications.
- Binds to ribosome-RNA complexes within single cells.
- Used for single-cell translatome sequencing.
- Can penetrate single cells (mouse oocytes, zebrafish embryo cells, HeLa cells) at concentrations of 50-1000 μM for 30 seconds to 30 minutes.
Medchemexpress LLC Pomalidomide-5'-PEG5-C2-COOH | 2412056-50-7 | 565.57 | 100 MG
Pomalidomide-5'-PEG5-C2-COOH is an active compound and drug derivative used for various biochemical research purposes. This compound requires specific storage conditions to maintain its stability.
- Active compound and drug derivative
- Store at -20°C, protected from light, and under nitrogen
- In solvent, store at -80°C for 6 months or -20°C for 1 month, protected from light and under nitrogen
- Soluble in DMSO at 100 mg/mL (176.81 mM; requires ultrasonic)
- Molecular formula: C₂₆H₃₅N₃O₁₁
Medchemexpress LLC DBCO-PEG6-NHS ester | 96.0% | 737.79 | 5 MG
DBCO-PEG6-NHS ester is a click chemistry PEG reagent that contains an NHS ester. This NHS ester specifically reacts with primary amines, such as the side chains of lysine residues or aminosilane-coated surfaces, forming covalent bonds efficiently under neutral or slightly alkaline conditions. Additionally, DBCO-PEG6-NHS ester includes a DBCO group, which can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Reacts specifically with primary amines.
- Contains a DBCO group for SPAAC with Azide groups.
Medchemexpress LLC DSPE-PEG-folate | 90.0% | 2000 g/mol (average) | C63H104N9O15P | 10 MG
DSPE-PEG-Folate is a PEGylated phospholipid supplied as a powder that presents folic acid as a targeting ligand for folate receptor-mediated delivery. It self-assembles into micelles or lipid bilayers and is intended for use in liposome formulation and targeted drug delivery research.
- Average molecular weight ~2000 g/mol.
- Purity 90.0%.
- Powder; light yellow to yellow.
- Soluble in DMSO at 50 mg/mL (requires ultrasonic).
- Storage: powder -20°C; in solvent -80°C (6 months) or -20°C (1 month).
- Forms micelles and lipid bilayers for receptor-targeted delivery.
Medchemexpress LLC PEG3-C4-OBn | 2381196-79-6 | 99.3% | 500 MG
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. It is utilized in the synthesis of PROTAC SGK3 degrader-1.
- Polyethylene glycol (PEG)-based PROTAC linker
- Utilized in the synthesis of PROTAC SGK3 degrader-1
- Key component for protein degradation studies
- Potential inhibitor for SGK3 related research
Medchemexpress LLC Dspe-pSar50 (dspe-polysarcosine50) | 99.91% | 1 MG
DSPE-pSar50 (DSPE-Polysarcosine50) is a pSar-lipid derivative. It is a hydrophilic alternative to PEG and can be used in drug delivery research.
- PSar-lipid derivative
- Hydrophilic alternative to PEG
- Can be used in drug delivery research
eMolecules 2055103-66-5 | Carboxyrhodamine 110-PEG4-alkyne | Broadpharm | MFCD30458035 | 587.629 | C32H33N3O8 | 85.000 | Nc1ccc2c(-c3ccc(cc3C(O)=O)C(=O)NCCOCCOCCOCCOCC#C)c3ccc(=N)cc3oc2c1 | 25mg | 340377112
Carboxyrhodamine 110-PEG4-alkyne | Broadpharm | 2055103-66-5 | MFCD30458035 | 587.629 | C32H33N3O8 | 85.000 | Nc1ccc2c(-c3ccc(cc3C(O)=O)C(=O)NCCOCCOCCOCCOCC#C)c3ccc(=N)cc3oc2c1 | 25mg | 340377112
Cayman Chemical VH 032 LInker 1 100mg
A PROTAC precursor; has been used in the synthesis of PROTACs targeting TEAD in cancer cells
Medchemexpress LLC PEG5-Tos | 155130-15-7 | 96.9% | 392.46 | 1 G
PEG5-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs (Proteolysis Targeting Chimeras) consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
Medchemexpress LLC Amino-PEG4-C2-SH hydrochloride | 95.0% | 289.82 g/mol | C10H24ClNO4S | 5 MG
Amino-PEG4-C2-SH hydrochloride is a PEG-based PROTAC linker supplied as the hydrochloride salt for research use. The molecule features a PEG4 spacer with a terminal amino group and a terminal thiol, enabling orthogonal conjugation strategies in bifunctional molecule synthesis. It is provided with characterized purity and molecular weight suitable for medicinal chemistry and linker development applications.
- Hydrochloride salt for improved handling and stability.
- Terminal amino and thiol groups for orthogonal conjugation.
- PEG4 spacer provides flexibility and aqueous solubility.
- Characterized purity for research-grade synthesis.
- Intended for use in PROTAC and linker chemistry.
Medchemexpress LLC PEG5-(CH2CO2H)2 | 77855-75-5 | MFCD29079379 | 99.3% | 310.30 | C12H22O9 | 1G
HOOCCH2O-PEG4-CH2COOH is a symmetric PEG-based dicarboxylic acid linker used as a flexible, hydrophilic spacer for the construction of bifunctional degraders and other conjugates. It provides two carboxylic acid termini for standard coupling chemistries, and its PEG4 backbone imparts solubility and conformational flexibility suited for PROTAC and homo-PROTAC synthesis.
- Symmetric PEG4 dicarboxylic acid linker.
- Provides carboxylic acid termini for straightforward coupling reactions.
- PEG backbone increases solubility and flexibility.
- Designed for use in PROTAC and homo-PROTAC synthesis.
- High purity suitable for research applications.
- Typically supplied in small pack sizes for lab-scale synthesis.
eMolecules m-PEG8-BBTA | Broadpharm |742.840 | C36H46N4O11S | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc2nc(oc2c1)-c1ccc(s1)-c1nc2ccc(N)cc2o1 | 1mg | 518001028
m-PEG8-BBTA | Broadpharm |742.840 | C36H46N4O11S | 95.000 | COCCOCCOCCOCCOCCOCCOCCOCCC(=O)Nc1ccc2nc(oc2c1)-c1ccc(s1)-c1nc2ccc(N)cc2o1 | 1mg | 518001028